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Sleep Support - What is It?

 

More people suffer from sleep issues than you might realize. A number of natural ingredients have been studied for their ability to support healthy sleep. Magnesium and melatonin are associated with sleep in numerous research studies. A number of other ingredients also have been shown to reduce sleeplessness or to promote sleep.

 

What is it for?

Sleep Time contains a range of herbs and micronutrients that research has shown to promote sleep, naturally.

A lack of sleep in the short term can lead to bad moods and lack of focus. Over time, however, a chronic lack of sleep can increase you risk of serious medical conditions like obesity, heart disease, and diabetes. In can even shorten your life expectancy (1).

Most specialists recommend about 8 hours of high-quality sleep to provide our brains and bodies with the rest they need to function properly (2).

 

Research-Based Benefits

According to specialists at the UK’s NHS, some of the benefits of getting enough good-quality over the long-term include:

  • Sleep boosts immunity
  • Sleep can slim you
  • Sleep boosts mental wellbeing
  • Sleep prevents diabetes
  • Sleep increases sex drive
  • Sleep wards off heart disease
  • Sleep increases fertility (1)

In the research summary below, evidence shows how each of the ingredients in Stride Nutrition’s Sleep Time formula helps to increase the length and quality of sleep.

 

Recommended for:*

  • People who have trouble falling asleep
  • People who regularly wake up in the middle of the night
  • People who wake up feeling groggy
  • People who are chronically sleep-deprived

 

*These are general recommendations and do not replace medical prescriptions or recommendations.

 

Stride's Product

Stride Nutrition’s Sleep Time multivitamin formula contains seven herb extracts and minerals that help to support normal sleep. The Stride Nutrition blend contains:

  • Magnesium (from magnesium citrate) - 20 mg
  • Hops Flowers 4:1 Extract (Humulus lupulus) - 100 mg
  • Lemon Balm Leaf (Melissa officinalis) - 100 mg
  • Chamomile Flower Standardized Extract (Matricaria recutita) - 75 mg
  • Passionflower Herb 4:1 Extract (Passiflora incarnata) - 50 mg
  • 5-Hydroxytryptophan (5-HTP from Griffonia simplicifolia seed) - 25 mg
  • Melatonin - 1 mg

 

 

Research Summary:

Outcome

Findings

Dose

Study Reference

Improvements in quality of sleep and morning alertness

PR-melatonin significantly improved quality of sleep, changes in sleep quality and morning alertness compared with placebo. The improvements in changed in sleep quality and morning alertness were strongly correlated suggesting a beneficial treatment effect on the restorative value of sleep.

2mg prolonged release melatonin over 3-weeks

(3)

Improved sleep quality

The findings, however, suggest an association between magnesium status and sleep quality that needs further study to definitively determine whether a low magnesium status is a cause or an effect of poor sleep quality.

320 mg magnesium per day

(4)

Improved sleep quality with aging

Magnesium supplementation led to a significant increase in slow wave sleep.

10-20 mmol of magnesium for 14 days

(5)

Humulus lupulus has sedating effects

Preparations reduced the spontaneous locomotor activity, increased the ketamine-induced sleeping time and reduced body temperature, confirming a central sedating effect.

Though the α-bitter acids proved to the be most active constituents, the β-bitter acids and the hop oil clearly contributed to the sedating activity of lipophilic Humulus extracts.

Not provided

(6)

Decrease in nocturnal activity

The dose of 2 mg, there was a statistically significant reduction of the arithmetic mean nocturnal activity with respect to the basal, control and other doses groups 1 mg and 11 mg.

 

The concentration of 2 mg of hop extract effectively decreased nocturnal activity in the circadian activity rhythm.

1, 2, and 11mg doses, one per day for one week.

(7)

Relieved stress-related effects

As much as 95% of subjects responded to treatment with Melissa officinalis L, of which 70% achieved full remission for anxiety, 85% for insomnia, and 70% for both. Our study demonstrates, for the first time that chronic administration of Melissa officinalis L. relieves stress-related effects.

Dose not provided, over 15 days.

(8)

Improved restlessness and dyssomnia in younger children.

In total, 80.9% of the patients who suffered from dyssomnia experienced an improvement for this symptom and 70.4% of the patients with restlessness improved clearly. For the other listed symptoms the total improvement was 37.8% on average. Both, parents and investigators assessed efficacy as to be “very good” or “good” (60.5% and 67.7%, respectively).

Individual doses by subject weight.

(9)

Sedative effect

In the present study, the methanol extract of Matricaria chamomilla

flower, at the intraperitoneal (IP) dose 300 mg/kg, showed considerable restful effect

300 mg/kg of Chamomile extract

(10)

Improves short-term subjective sleep.

Of six sleep‐diary measures analysed, sleep quality showed a significantly better rating for passionflower compared with placebo (t(40) = 2.70, p < 0.01). These initial findings suggest that the consumption of a low dose of Passiflora incarnata, in the form of tea, yields short‐term subjective sleep benefits for healthy adults with mild fluctuations in sleep quality.

Passiflora incarnata herbal tea, dose not specified.

(11)

Increases REM sleep

In each subject, rapid eye movement (REM) sleep increased from 5 to 53% of placebo baseline with 5-hydroxytryptophan (5-HTP) supplementation.

Dose not specified.

(12)

Modulated arousal level in children and induced long-term improvement of sleep terrors

After 1 month of treatment, 29/31 (93.5%) of patients showed a positive response. In the comparison group without drug therapy, after 1 month, the episodes disappeared only in four children (28.6%) while ten children (71.4%) showed the persistence of episodes with the same frequency as before. After 6 months, 26/31 (83.9%) of children treated with l -5HTP were sleep terror-free, while in five children (16.1%) sleep terror episodes persisted. Of the children in the comparison group, ten (71.4%) continued to show sleep terrors at 6-month follow-up.

2 mg/kg per day 5-HTP

(13)

Decrease in sleep-onset latency

The 5 trials including 91 adults and 4 trials including 226 children showed that melatonin treatment advanced mean endogenous melatonin onset by 1.18 hours and clock hour of sleep onset by 0.67 hours. Melatonin decreased sleep-onset latency by 23.27 minutes. The wake-up time and total sleep time did not change significantly.

Meta-analysis

(14)

 

 

References:

  1. https://www.nhs.uk/live-well/sleep-and-tiredness/why-lack-of-sleep-is-bad-for-your-health/
  2. https://www.sleepfoundation.org/how-sleep-works/how-much-sleep-do-we-really-need
  3. https://www.ncbi.nlm.nih.gov/pubmed/18036082
  4. https://www.ncbi.nlm.nih.gov/pubmed/21199787
  5. https://www.ncbi.nlm.nih.gov/pubmed/12163983
  6. https://www.sciencedirect.com/science/article/pii/S0944711306001000
  7. https://akademiai.com/doi/abs/10.1556/APhysiol.99.2012.2.6
  8. https://content.iospress.com/articles/mediterranean-journal-of-nutrition-and-metabolism/mnm4-3-09
  9. https://www.sciencedirect.com/science/article/pii/S0944711306000250
  10. https://www.researchgate.net/profile/Yousef_Taher/publication/305568159_CNS_depressant_activity_of_Chamomile_methanol_extract_in_mice/links/5793ce3308aed51475c28e75.pdf
  11. https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.3400
  12. https://www.clinph-journal.com/article/0013-4694(71)90147-7/fulltext
  13. https://link.springer.com/article/10.1007/s00431-004-1444-7
  14. https://academic.oup.com/sleep/article/33/12/1605/2433770